Neil Shear, Jerome Z. Litt
Abstract
Death (2003): Edwards IR, Lancet 361, 1240 (11 cases) Dysgeusia (2%) Foetor ex ore (halitosis) (<1%) Gingivitis (<1%) Glossitis (<1%) Gynecomastia (<1%) Headache Hyperesthesia (<1%) Mastodynia (1%) Myalgia Oral candidiasis (<1%) Oral ulceration (<1%) Paresthesias (4%) (1999): Litt JZ, Beachwood, OH (personal case) (observation) Priapism (<1%) (1999): Brodie-Meijer CC+, Int Clin Psychopharmacol 14, 257 (clitoral) Rhabdomyolysis (2002): Thompson M+, Am J Psychiatry 159(9), 1607 (with simvastatin) Sialorrhea (<1%) Stomatitis (<1%) Vaginitis (2%) Xerostomia (25%) Trade name: Viracept (Pfizer) Indications: HIV infection Category: Antiretroviral; Protease inhibitor Half-life: 3.5-5 hours Clinically important, potentially hazardous interactions with: benzodiazepines, chlordiazepoxide, clonazepam, clorazepate, diazepam, dihydroergotamine, ergot alkaloids, fentanyl, flurazepam, lorazepam, methysergide, midazolam, oral contraceptives, oxazepam, phenytoin, pimozide, quazepam, rifampin, sildenafil, St John’s wort, temazepam Reactions Skin Allergic reactions (sic) (<1%) Dermatitis (sic) (<1%) Diaphoresis (<1%) Exanthems (1998): Bourezane Y+, Clin Infect Dis 27(5), 1321 (with indinavir) Hyperhidrosis (2000): Bonfanti P+, J Acquir Immune Defic Syndr 23(3), 236 Lichenoid eruption (1998): Bourezane Y+, Clin Infect Dis 27(5), 1321 Palmar erythema (1998): Bourezane Y+, Clin Infect Dis 27(5), 1321 (with indinavir) Pruritus (<1%) Rash (sic) (1-10%) (2001): Abraham PE+, Ann Pharmacother 35(5), 553 (2000): Fortuny C+, AIDS 14, 335 Urticaria (<1%) (1998): Demoly P+, J Allergy Clin Immunol 102(5), 875 Vasculitis (1998): Bourezane Y+, Clin Infect Dis 27(5), 1321 Other DRESS syndrome (1998): Bourezane Y+, Clin Infect Dis 27, 1321 Gynecomastia (2001): Manfredi R+, Ann Pharmacother 35(4), 438…
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