2026Journal article
Essawy AS, Abo Elkhair DM
Tissue & cell
In industry, acrylamide (ACR) is generated by heating tobacco and carbohydrate-rich foods. In the past decade, ACR neurotoxicity has become a growing concern. This study examined matcha green tea (MAT)'s protective effect against cerebellar toxicity induced by ACR and its neuroprotective mechanisms in rats. Forty male albino rats were divided randomly into four experimental groups: control group, MAT group (150 mg/kg), ACR group (50 mg/kg), and ACR + MAT group. Oxidative stress and inflammatory biomarkers in cerebellar tissue (superoxide dismutase; SOD, catalase; CAT, glutathione peroxidase; GPx, malondialdehyde; MDA, tumor necrosis factor-alpha; TNF-α and Interleukin 6; IL-6) were assessed. Cerebellar tissues were exposed to histological, immunohistochemical, and ultrastructural evaluations. Significant decline in the SOD, CAT, and GPx levels together with significant rise in the levels of MDA, TNF-α, and IL-6 were observed in ACR group. Histologically, the ACR group showed variable degrees of cellular degeneration with marked reduction of Nissl's granules. This was verified by electron microscopic examination and strong positive reaction for GFAP, NF-κB and caspase -3. Rats treated by ACR + MAT showed improvement of the biochemical, histological and ultrastructural parameters. This was confirmed by the significant diminution in caspase-3, NF-κB & GFAP immunostaining. In conclusion, matcha green tea amended the alterations in the cerebellum induced by ACR through modulation of inflammation, oxidative stress and apoptosis.
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Study type
Animal study
Experiments in mice, rats, fish or other animals.
Assigned automatically from the title, abstract and subject terms.
Topics
Matcha is a main subject here (named in the title).
Essawy AS, Abo Elkhair DM. (2026). Matcha green tea attenuates acrylamide-induced cerebellar damage in rats: Biochemical, histological and immunohistochemical study. Tissue & cell. https://doi.org/10.1016/j.tice.2026.103726
DOI: 10.1016/j.tice.2026.103726 · PubMed ID: 42341430
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