2022Journal article
Kazuhiko Uchida, Kohji Meno, Hideaki Suzuki, Tatsumi Korenaga, Hitomi Ito, Makoto Inoue, Shan Liu, Miho Ota, Noeru Shiraki, Shin Nakamura, Satoshi Yomota, Nobuyuki Akinaga, and 11 more
Alzheimer s & Dementia
Abstract Background Nutrition is a pivotal factor in the prevention of dementia. Matcha green tea powder, which contains L‐theanine, caffeine, and epigallocatechin gallate, has the beneficial effects of each constituent on cognitive functions and mood. However, no long‐term clinical study has yet been performed to evaluate the effect of Matcha on psychological functions. Here, we performed a randomized, double‐blinded, placebo‐controlled, clinical study, conducted over 12 months, to investigate the effect of Matcha on cognitive functions and sleep quality. Furthermore, the relationship between blood and neuroimaging biomarkers and the effect of Matcha was investigated. Methods We recruited 939 community‐dwelling older adults aged 60–84 years and enrolled subjects with a diagnosis of subjective cognitive decline (SCD) and mild cognitive impairment (MCI). A total of 99 subjects (64 SCD, 35 MCI) were randomized, with 49 receiving Matcha (2 g/day, male 23, female 26) and 50 receiving placebo (male 20, female 30). The groups were adjusted for age, sex, and APOE4 genotype. Cognitive functions were assessed by MMSE, MoCA, ADAS‐cog, RBANS, and the CNS Vital Signs computerized neurocognitive battery. Sleep quality was measured by the Pittsburg Sleep Quality Index (PSQI). Plasma biomarkers and neuroimaging (Amyloid PET, MRI, SPECT, fNIRS) were also assessed. The change of outcome variables from the baseline to 12‐month was tested statistically using a mixed‐effects model. Results Compared to the placebo, the consumption of Matcha induced a significant improvement in social acuity assessed by perception of facial emotion (P = 0.034), while continuous performance showed a trend towards improvement. The PSQI differed by 0.86 between the groups, indicating an improvement in sleep…
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Study type
Randomized controlled trial
People were randomly assigned to matcha or a comparison.
Assigned automatically from the title, abstract and subject terms.
Topics
Matcha is a main subject here (named in the title).
Kazuhiko Uchida, Kohji Meno, Hideaki Suzuki, Tatsumi Korenaga, Hitomi Ito, Makoto Inoue, … Takanobu Takihara. (2022). Effect of Matcha green tea on cognitive functions and sleep quality in elderly adults with cognitive decline: a randomized controlled study over 12 months. Alzheimer s & Dementia. https://doi.org/10.1002/alz.069150
DOI: 10.1002/alz.069150 · Cited by 1 (OpenAlex)
Japanese matcha is a type of powdered green tea, grown in a traditional way. Shading of the plants during the growth period enhances the processes of synthesis and accumulation of biologically active compounds, including theanine,…
ReviewCognition, mood and stressAntioxidants and polyphenolsL-theanine and caffeineCited 321×Theanine, a major amino acid in green tea, exhibits a stress-reducing effect in mice and humans. Matcha, which is essentially theanine-rich powdered green tea, is abundant in caffeine. Caffeine has a strong antagonistic effect against…
Randomized controlled trialCognition, mood and stressAntioxidants and polyphenolsL-theanine and caffeineCited 84×Background: Green tea is traditionally known to induce mental clarity, cognitive function, physical activation and relaxation. Recently, a special green tea, matcha tea, is rapidly gaining popularity throughout the world and is frequently…
ReviewCognition, mood and stressAntioxidants and polyphenolsL-theanine and caffeineCited 70×Matcha tea is gaining popularity throughout the world in recent years and is frequently referred to as a mood-and-brain food. Previous research has demonstrated that three constituents present in matcha tea, l-theanine, epigallocatechin…
Randomized controlled trialCognition, mood and stressAntioxidants and polyphenolsL-theanine and caffeineCited 66×